Right-sided cardiac echocardiographic parameters show no major change during 3-months mavacamten treatment in obstructive hypertrophic cardiomyopathy

Abstract Background Clinical guidelines indicate the use of the cardiac myosin inhibitor mavacamten for the treatment of symptomatic adult patients with obstructive HCM (oHCM) as it normalizes contractility, reduces dynamic left ventricular outflow tract (LVOT) obstruction, and improves cardiac filling pressures. Purpose In our study we aimed to investigate the effect of mavacamten treatment on right-sided echocardiographic parameters. Methods Thirty-nine oHCM patients [21 men (54%), mean age: 56±11 years] were treated with mavacamten. In addition to recording the main demographic and clinical parameters, complete standard, 2D-speckle tracking and 3D volumetric and speckle tracking echocardiographic examination was performed in four-week intervals of treatment until 12 weeks (W12). Results As a main effect, resting peak LVOT gradient was significantly reduced (average reduction of -57 mmHg at W12,