Echocardiographic parameters of left ventricular diastolic dysfunction, left atrial volumes and left atrial function improves in obstructive hypertrophic cardiomyopathy during mavacamten treatment

Abstract Background/Objectives The selective cardiac myosin inhibitor mavacamten, is indicated for the treatment of symptomatic, NYHA II-III class adult patients with obstructive hypertrophic cardiomyopathy [oHCM, ≥ 50 mmHg resting or provokable left ventricular outflow tract (LVOT) peak gradient]. As real-world data on the efficacy of the drug are relatively scarce, we aimed to investigate the effect of mavacamten treatment on echocardiographic parameters of left ventricular (LV) diastolic dysfunction and left atrial (LA) function. Patients and Methods Thirty-nine oHCM patients [21 men (54%), mean age: 56±11 years] were treated with mavacamten. In addition to recording the main demographic and clinical parameters, complete standard, 2D-speckle tracking and 3D volumetric and speckle tracking echocardiographic examination was performed in four-week intervals of treatment until 12 weeks (W12). Results With the decrease of the resting peak LVOT gradient (average reduction of -57 mmHg at W12,