Cardiac magnetic resonance-derived left atrial strain restratifies patients with hypertrophic cardiomyopathy at low-risk of sudden cardiac death

European Heart Journal - Cardiovascular Imaging 2026

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Authors: Andrea Faggiano, Guillem Casas, Francisco Gonzalez‐Santorum, Arnau Subira-Ingla, Matteo Brusamolino, Claudio Tomasino, D Miccoli, Jorge Rodrigo Fernandez, M Soledad Ceballos, Pablo Escribano-Escribano, Giulia Ricci, Javier Limeres
+5 more Gisela Teixidó, Eduard Ródenas-Alesina, Andrea Guala, Ignacio Ferreira-Gonzalez, Jose F. Rodríguez Palomares
DOI: 10.1093/ehjci/jeag049
Cited by: 4
References: 35

Abstract

AIMS: Hypertrophic cardiomyopathy (HCM) is associated with diverse cardiovascular outcomes. Whilst the HCM Risk-SCD score effectively stratifies sudden cardiac death (SCD) risk, it provides limited insight into global cardiovascular prognosis, particularly amongst low-risk patients (HCM Risk-SCD score 5% of total myocardial mass (HR 2.00, 95% CI 1.01-3.97, P = 0.049), and LV ejection fraction (LVEF) < 50% (HR 12.86, 95% CI 5.91-33.66, P < 0.001). Patients with LVEF >50%, LGE 37.6% had a MACE rate of only 2%, identifying an overall low-risk subgroup. The prognostic value of LA-GLS was validated in an external cohort of 202 low-risk HCM patients. CONCLUSION: CMR-derived LA-GLS improves risk stratification in HCM patients at low-risk of SCD and may refine management strategies and optimize resource allocation.

Fields of Study & Subjects

Cardiovascular Function and Risk Factors Cardiomyopathy and Myosin Studies Cardiac Imaging and Diagnostics

Publication details

Journal / source
European Heart Journal - Cardiovascular Imaging
Publisher
Oxford University Press (OUP)
Volume
27
Issue
6
Pages
1268–1280
Publication date
17 February 2026
Language
EN