Lipoprotein(a) is associated with coronary inflammation in people with HIV and undetectable HIV RNA

European Heart Journal - Imaging Methods and Practice 2026 Open access

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Authors: Nadim Nasrallah, Tarek H. Harb, Atallah, Gary Gerstenblith, Sabina Haberlen, Theodoros Kelesidis, Jared Magnani, Valentina Stosor, Kenneth Chan, Cheerag C. Shirodaria, Henry W. West, Todd T Brown
+4 more Allison G. Hays, Wendy S Post, Charalambos Antoniades, Thorsten Martin Leucker
DOI: 10.1093/ehjimp/qyag040
Cited by: 1
References: 41

Abstract

Abstract Aims People with HIV (PWH) and undetectable virus experience elevated cardiovascular risk independent of traditional risk factors. Vascular inflammation may contribute to this residual risk. The perivascular fat attenuation index (FAI), derived from coronary computed tomography angiography (CCTA), is a biomarker of coronary inflammation. Lipoprotein(a) [Lp(a)] carries oxidized phospholipids that may promote inflammation. Statins have demonstrated cardiovascular benefit in PWH, including pleiotropic anti-inflammatory effects. This study assessed the associations of Lp(a) and of statin use with coronary inflammation (FAI) in men with HIV (MWH). Methods and results We analysed FAI of the left anterior descending (LAD) and the right coronary arteries (RCA) in 583 men from the Multicenter AIDS Cohort Study, a prospective, multicentre cohort study, including 280 with undetectable HIV RNA,

Fields of Study & Subjects

Cardiovascular Disease and Adiposity HIV-related health complications and treatments Lipoproteins and Cardiovascular Health

Publication details

Journal / source
European Heart Journal - Imaging Methods and Practice
Publisher
Oxford University Press (OUP)
Volume
4
Issue
1
Pages
qyag040–qyag040
Publication date
1 January 2026
Language
EN