Severe LVOT obstruction in HCM: effects on exercise capacity and outcomes from cardiopulmonary exercise testing combined with stress echocardiography

European Heart Journal - Quality of Care and Clinical Outcomes 2026

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Authors: Raffaella Mistrulli, Federica Re, Guido Giacalone, Tatyana Storozhenko, Paolo Ciacci, Anna Di Cristo, A Ferrera, Domenico Gabrielli, Géza Hálasz
DOI: 10.1093/ehjqcco/qcag056
Cited by: 2
References: 27

Abstract

AIMS: Hypertrophic cardiomyopathy (HCM) is a complex disease in which left ventricular outflow tract (LVOT) obstruction influences both functional capacity and clinical outcomes. However, the clinical relevance of varying obstruction severity remains debated. To evaluate the relationship between LVOT gradient severity and both exercise performance and long-term prognosis in HCM using combined cardiopulmonary exercise testing and stress echocardiography (TTE-CPET). METHODS AND RESULTS: We retrospectively analysed 388 HCM patients undergoing TTE-CPET, stratified into four groups based on peak LVOT gradient:

Fields of Study & Subjects

Cardiovascular Effects of Exercise Cardiovascular and exercise physiology Atrial Fibrillation Management and Outcomes

Publication details

Journal / source
European Heart Journal - Quality of Care and Clinical Outcomes
Publisher
Oxford University Press (OUP)
Volume
12
Issue
6
Pages
1111–1122
Publication date
4 April 2026
Language
EN