Divergent roles of skeletal muscle 11β-HSD1 in age-related and chronic kidney disease-associated sarcopenia

European Journal of Endocrinology 2026 Open access

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Authors: Michael S. Sagmeister, Ana Crastin, Bradley Welsh, Louise Firkins, Ben Cassidy, Thomas A. Nicholson, Sophie J. Hopkin, Nadezhda A. Wall, Angela E Taylor, Julius E. Kieswich, Maidah Yaqoob, Gareth Lavery
+7 more Myriam Chimen, Helen Michelle McGettrick, Asif J Iqbal, Leigh Breen, Simon Wyn Jones, Lorraine Harper, Rowan S Hardy
DOI: 10.1093/ejendo/lvag075
Cited by: 1
References: 38

Abstract

BACKGROUND: Chronic kidney disease (CKD) is associated with increased incidence of sarcopenia and muscle weakness in aging patients. The glucocorticoid-activating enzyme11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) within skeletal muscle in these patients has been implicated in driving this process. We hypothesized that skeletal muscle 11β-HSD1 is elevated in CKD and aging, where it would represent a promising therapeutic target. METHODS: We measured 11β-HSD1 activity in quadriceps biopsies from 17 CKD patients (eGFR

Fields of Study & Subjects

Hormonal Regulation and Hypertension Estrogen and related hormone effects Adrenal Hormones and Disorders

Publication details

Journal / source
European Journal of Endocrinology
Publisher
Oxford University Press (OUP)
Volume
194
Issue
5
Pages
627–640
Publication date
30 April 2026
Language
EN