Mortality and heart failure hospitalizations in heart failure with preserved ejection fraction compared to heart failure with reduced ejection fraction: a systematic review and meta-analysis

ESC Heart Failure 2026 Open access

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Authors: Krzysztof Irlik, Julia Piaśnik, Mirela Hendel, Urszula Faron, GY Lip, Katarzyna Nabrdalik, Konstantinos Prokopidis
DOI: 10.1093/eschf/xvag026
Cited by: 3
References: 28

Abstract

INTRODUCTION: The global burden of heart failure (HF) is rising, with a shift towards more cases of heart failure with preserved ejection fraction (HFpEF). Given evolving epidemiology, an updated assessment of outcome differences between HFpEF and heart failure with reduced ejection fraction (HFrEF) is needed. This systematic review and meta-analysis aimed to provide a contemporary, large-scale comparison of clinical outcomes between HFpEF and HFrEF. METHODS: A systematic review and meta-analysis were conducted to compare all-cause mortality, cardiovascular (CV) mortality, and HF hospitalizations in HFpEF (EF: >50%) and HFrEF (EF:

Fields of Study & Subjects

Heart Failure Treatment and Management Cardiovascular Function and Risk Factors Cardiac pacing and defibrillation studies

Publication details

Journal / source
ESC Heart Failure
Publisher
Oxford University Press (OUP)
Volume
13
Issue
1
Publication date
14 January 2026
Language
EN