Two to Tango: lipoprotein(a) and hormonal status as determinants of venous thromboembolism risk
Abstract
Complementary prothrombotic mechanisms of lipoprotein(a) [Lp(a)] and oestrogen. Oestrogen increases venous thromboembolism (VTE) risk through interactions with the coagulation system. Additionally, Lp(a) has proposed anti-fibrinolytic mechanisms, primarily demonstrated in in vitro studies. The present study, based on data from the UK Biobank, suggests that Lp(a) is associated with increased VTE risk in the setting of increased circulating oestrogen, either in premenopausal women or postmenopausal women on hormone replacement therapy. The figure illustrates a potential “two-hit” interaction between oestrogen and Lp(a), which may be associated with increased risk of VTE. Figure designed by the authors using an AI tool.
Fields of Study & Subjects
Venous Thromboembolism Diagnosis and Management
Blood Coagulation and Thrombosis Mechanisms
Blood properties and coagulation
Publication details
- Journal / source
- European Heart Journal
- Publisher
- Oxford University Press (OUP)
- Volume
- 47
- Issue
- 27
- Pages
- 3588–3590
- Publication date
- 24 March 2026
- Language
- EN