Optimal serum potassium concentrations in heart failure: an individual patient data meta-analysis

European Heart Journal 2026 Open access

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Authors: Ryohei Ono, Misato Chimura, Kieran F. Docherty, Alasdair D Henderson, Ross Campbell, Akshay S. Desai, Michel Komajda, Milton Packer, Marc A Pfeffer, Bertram Pitt, John R Teerlink, Faiez Zannad
+6 more Muthiah Vaduganathan, Orly Vardeny, Mingming Yang, Pardeep S Jhund, Scott D Solomon, John J V McMurray
DOI: 10.1093/eurheartj/ehag341
Cited by: 3
References: 48

Abstract

BACKGROUND AND AIMS: It remains unclear what the safe serum potassium range is in heart failure (HF) and whether it is the same in HF with reduced ejection fraction (HFrEF) and HF with preserved ejection fraction (HFpEF). METHODS: A patient-level pooled analysis from 12 randomized controlled trials including 32 346 HFrEF and 13 723 HFpEF patients was performed. Baseline serum potassium level was categorized into six groups (

Fields of Study & Subjects

Potassium and Related Disorders Heart Failure Treatment and Management Sodium Intake and Health

Publication details

Journal / source
European Heart Journal
Publisher
Oxford University Press (OUP)
Volume
47
Issue
32
Pages
4480–4499
Publication date
17 April 2026
Language
EN