Sex-specific associations between depression and cardiovascular–kidney–metabolic syndrome progression: a national cohort study

European Journal of Preventive Cardiology 2026

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Authors: Qi Gao, Weirong Ren, Xingguo Du, Yaping Yu, Zhou Ma, Yan Cui, Xiaohong Song, Zhongcai Wu, Zhiqin Zhang, Qianqian Liao, Ming Tian, Honglan Wei
+1 more Junwu Dong
DOI: 10.1093/eurjpc/zwag135
Cited by: 4
References: 50

Abstract

AIMS: Depressive symptoms are common in women and men with cardiovascular-kidney-metabolic (CKM) syndrome components, yet their prognostic relevance to CKM progression remains unclear. We therefore investigated the sex-specific associations between depressive symptoms and the risk of CKM progression in a national cohort of middle-aged and elderly adults. METHODS: A total of 5,035 participants aged ≥45 years with CKM stages 0-3 were enrolled. Depressive symptoms were measured using the ten-item Center for Epidemiologic Studies Depression (CESD-10) scale, with scores

Fields of Study & Subjects

Dialysis and Renal Disease Management Cardiac Health and Mental Health Chronic Kidney Disease and Diabetes

Publication details

Journal / source
European Journal of Preventive Cardiology
Publisher
Oxford University Press (OUP)
Volume
33
Issue
13
Pages
2455-2466
Publication date
3 March 2026
Language
EN