Cardiovascular risk in inflamed Danish women and men without standard modifiable risk factors

AIMS: Elevated hsCRP levels correlate with high risk of cardiovascular disease in American women without standard modifiable cardiovascular risk factors ("SMuRF-less"). We examined whether elevated hsCRP levels are associated with cardiovascular risk in low-risk Danish women and men without standard modifiable risk factors using a prospective cohort design. METHODS: We included all SMuRF-less and SCORE2/SCORE2-OP/PREVENT low-risk individuals aged 20-100 years without cardiovascular disease from the Copenhagen General Population Study. Using cause-specific Cox models, we constructed age and sex adjusted cumulative incidence curves and calculated multivariable adjusted hazard ratios for major adverse cardiovascular events (MACE), coronary heart disease, and ischaemic stroke across baseline hsCRP clinical thresholds (