C-Type lectin receptors as key modulators of intestinal inflammation: insights into IBD pathogenesis and therapy

This review focuses on the role of C-type lectin receptors (CLRs) in inflammatory bowel disease (IBD). It outlines their classification, structural features, and functional mechanisms within intestinal immunity. The article comprehensively examines recent advances in understanding the contributions of specific CLRs-including Dectin-1, Mincle, Dectin-3, and the mannose receptor (MR/CD206)-to IBD pathogenesis, particularly their functions in microbial recognition, immune cell activation, and the regulation of inflammatory responses. Finally, the review addresses current research challenges and future directions, with the aim of providing deeper insights into disease mechanisms and facilitating the development of novel CLR-targeted therapies.