Association between ovarian reserve and utilization of preimplantation genetic testing for aneuploidy in autologous IVF cycles

Abstract STUDY QUESTION Does ovarian reserve, as measured by anti-Müllerian hormone (AMH), influence the utilization of preimplantation genetic testing for aneuploidy (PGT-A) in autologous IVF cycles across different age groups? SUMMARY ANSWER Lower ovarian reserve, reflected by reduced AMH levels, was associated with a lower likelihood of undergoing PGT-A across all age strata. WHAT IS KNOWN ALREADY PGT-A is widely used in IVF, particularly in older patients, but its utilization may be influenced not only by age but also by expected ovarian reserve and embryo yield. How ovarian reserve is associated with selection for PGT-A at a population level has not yet been well characterized. STUDY DESIGN, SIZE, DURATION This cross-sectional analysis of the US Society for Assisted Reproductive Technology Clinic Outcome Reporting System (SART CORS) database includes 258,532 patient-first autologous ovarian stimulation cycles performed between 2014 and 2021. PARTICIPANTS/MATERIALS, SETTING, METHODS The study included the first autologous IVF cycles of women aged 21–46 years. Donor oocyte, donor embryo, and gestational carrier cycles were excluded, as were cycles using