Revisiting the promise and pitfalls of mitochondrial replacement therapies
Abstract
Mitochondrial replacement therapies (MRTs) have been proposed as a means of avoiding the transmission of pathogenic mitochondrial DNA (mtDNA) mutations from mother to child. While clinical cases using this groundbreaking strategy have now been reported for the two principal MRT methods-pronuclear transfer and maternal spindle transfer-recent data continues to raise questions about the reliability of these approaches for disease prevention.
Fields of Study & Subjects
Mitochondrial Function and Pathology
Photosynthetic Processes and Mechanisms
Adipose Tissue and Metabolism
Publication details
- Journal / source
- Human Reproduction
- Publisher
- Oxford University Press (OUP)
- Volume
- 41
- Issue
- 4
- Pages
- 479–482
- Publication date
- 30 January 2026
- Language
- EN