Characterization of Mouse-Adapted Marburg and Ravn Viruses in Inbred BALB/c and Outbred CD-1 Mice

The Journal of Infectious Diseases 2026 Open access

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Authors: Katherine A Davies, Stephen R. Welch, JoAnn D Coleman-McCray, Teresa E. Sorvillo, Virginia Aida-Ficken, Shilpi Jain, César G. Albariño, Biao He, Christina F Spiropoulou, Jessica R. Spengler
DOI: 10.1093/infdis/jiag019
Cited by: 1
References: 13

Abstract

Marburgviruses cause severe hemorrhagic disease in humans, yet characterization of rodent models for pathogenesis and medical countermeasure development remains limited. Here, we investigated clinical course, blood chemistry, viral dissemination, and mucosal viral detection in inbred BALB/c and outbred CD-1 mice infected with mouse-adapted (MA)-Marburg virus (MARV)/Angola or MA-Ravn virus (RAVV) to further mouse model development. Regardless of virus or mouse strain, infection resulted in widespread viral dissemination in animals sampled up to 5 days post-infection. However, in animals followed to study end, MA-MARV/Angola caused severe disease and lethality in both mouse strains, whereas MA-RAVV caused mild or asymptomatic infection.

Fields of Study & Subjects

Viral Infections and Outbreaks Research Viral Infections and Vectors Vector-Borne Animal Diseases

Publication details

Journal / source
The Journal of Infectious Diseases
Publisher
Oxford University Press (OUP)
Volume
233
Issue
5
Pages
e1267–e1272
Publication date
7 January 2026
Language
EN