Incidence and Severity of Postacute Sequelae of SARS-CoV-2 Infection in the Omicron Era: A Prospective Cohort Study

The Journal of Infectious Diseases 2026

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Authors: Dan-Yu Lin, Melissa A Mischell, Xinyu Zhang, Katie R. Mollan, Ning Zhang, Dinelka Nanyakkara, Jessica Keys, Becky Straub, David Wohl, William Fischer
DOI: 10.1093/infdis/jiag026
Cited by: 1
References: 11

Abstract

In a prospective cohort study of 2960 nonhospitalized adults with acute SARS-CoV-2 infection, older age, female sex, rural residence, high body mass index, greater acute infection severity, chronic lung disease, and poorer general health at baseline were associated with higher risk and severity of postacute sequelae. Recent vaccination was associated with lower postacute sequelae risk and severity, while antiviral therapy was not.

Fields of Study & Subjects

Long-Term Effects of COVID-19 Pharmacological Receptor Mechanisms and Effects SARS-CoV-2 and COVID-19 Research

Publication details

Journal / source
The Journal of Infectious Diseases
Publisher
Oxford University Press (OUP)
Volume
233
Issue
6
Pages
1063–1068
Publication date
7 January 2026
Language
EN