Dynamics of Intact and Defective Human Immunodeficiency Virus Type 1 (HIV-1) Proviruses During Decades of Suppressive Antiretroviral Treatment in Young Adults With Perinatal HIV

The Journal of Infectious Diseases 2026 Open access

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Authors: Priya Khetan, Kunjal Patel, Wendy Yu, Joseph Szewczyk, Adit Dhummakupt, Sandra Burchett, Russell B. Van Dyke, Deborah Persaud
DOI: 10.1093/infdis/jiag045
Cited by: 2
References: 47

Abstract

BACKGROUND: Understanding HIV-1 reservoir dynamics during long-term antiretroviral therapy (ART) in youth with perinatal Human Immunodeficiency Virus Type-1 (HIV-1) is essential for ART-free remission strategies. METHODS: We quantified intact and defective HIV proviruses in 201 peripheral blood mononuclear cell samples (PBMCs) from participants ages 17.6-21.2 years in the Pediatric HIV/AIDS Cohort Study (PHACS) Adolescent Master Protocol. Participants were classified as early-suppressed (ES,

Fields of Study & Subjects

HIV Research and Treatment HIV/AIDS drug development and treatment HIV/AIDS Research and Interventions

Publication details

Journal / source
The Journal of Infectious Diseases
Publisher
Oxford University Press (OUP)
Volume
233
Issue
6
Pages
e1396–e1406
Publication date
26 January 2026
Language
EN