Limited Sex-Based Differences in Viral Outcomes of ART-Treated SIV/SHIV Infection

The Journal of Infectious Diseases 2026 Open access

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Authors: Kedan Endrias, Mr. Soham Shrikrishna Sonawane, Kirk A. Easley, Benedicth Ukhueduan, Michelle Lee, Vijayakumar Velu, Rama R Amara, Steven E. Bosinger, Mirko Paiardini, Guido Silvestri, Maud Mavigner, Vidisha Singh
+1 more Ann Chahroudi
DOI: 10.1093/infdis/jiag064
Cited by: 0
References: 22

Abstract

Lentiviral infection of rhesus macaques represents a robust model for HIV persistence and a key system to evaluate HIV cure-directed interventions. How sex impacts viral reservoirs in macaques is unknown. We sought to uncover potential sex differences in viral measurements during antiretroviral therapy using data from 19 studies conducted at Emory Primate Center. Sex differences in total and intact SIV/SHIV-DNA levels in blood and lymph node CD4+ T cells were not observed, although subgroup analysis of adult macaques with SIV revealed higher reservoir levels in females. Age (adult versus infant) was a significant effect for all viral outcomes studied.

Fields of Study & Subjects

HIV Research and Treatment HIV/AIDS drug development and treatment Virus-based gene therapy research

Publication details

Journal / source
The Journal of Infectious Diseases
Volume
233
Issue
6
Pages
e1418–e1422
Publication date
30 January 2026
Language
EN