Development of a risk prediction model for vancomycin-associated acute kidney injury: a multicentre retrospective study

Journal of Antimicrobial Chemotherapy 2026 Open access

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Authors: Tomoyuki Ishigo, Yumi Suzuki, Yuta Ibe, Satoshi Fujii, Masahide Fukudo, Hiroaki Yoshida, Hiroaki Tanaka, Hisato Fujihara, F Yamaguchi, Fumiya Ebihara, Takumi Maruyama, Yusuke Yagi
+11 more Yukihiro Hamada, Masaru Samura, Fumio Nagumo, Toshiaki Komatsu, Atsushi Tomizawa, Akitoshi Takuma, Hiroaki Chiba, Yoshifumi Nishi, Yuki Igarashi, Yuki Enoki, Kazuaki Matsumoto
DOI: 10.1093/jac/dkag012
Cited by: 1
References: 40

Abstract

OBJECTIVES: To clarify the relationship between acute kidney injury (AKI) and vancomycin use in patients with renal impairment and to establish a risk score for AKI. METHODS: In this retrospective, multicentre, observational cohort study, trough and peak blood samples were collected from patients who initiated vancomycin therapy. The cumulative incidence of AKI within 14 days was compared among three groups classified according to renal function (estimated glomerular filtration rate ≥ 60, 30-59 and 600 µg·h/mL: HR, 4.4, 95% CI (2.62-7.37), 3 points] were significantly related to the development of AKI. The predicted probabilities of AKI incidence were

Fields of Study & Subjects

Antimicrobial Resistance in Staphylococcus Acute Kidney Injury Research Antibiotics Pharmacokinetics and Efficacy

Publication details

Journal / source
Journal of Antimicrobial Chemotherapy
Publisher
Oxford University Press (OUP)
Volume
81
Issue
3
Publication date
11 January 2026
Language
EN