Impact of eravacycline on fibrinogen
Abstract
OBJECTIVES: While tigecycline has been associated with hypofibrinogenaemia, limited data with eravacycline suggest this may also occur with this agent. However, the incidence and clinical significance of this finding are not well defined. METHODS: This is a retrospective cohort study of hospitalized adults who received at least two doses of eravacycline between 1 August 2018 and 1 October 2024 and had two or more fibrinogen levels monitored while on therapy. The primary outcome was ≥50% reduction in fibrinogen while on eravacycline. Secondary outcomes included ≥25% reduction in fibrinogen, time to 50% fibrinogen reduction, development of hypofibrinogenemia (
Fields of Study & Subjects
Blood properties and coagulation
Streptococcal Infections and Treatments
Blood transfusion and management
Publication details
- Journal / source
- Journal of Antimicrobial Chemotherapy
- Publisher
- Oxford University Press (OUP)
- Volume
- 81
- Issue
- 3
- Publication date
- 14 January 2026
- Language
- EN