Tissue adaptation of eosinophils
Abstract
Eosinophils are increasingly recognized as tissue-resident immune cells that take on diverse functions. Recent studies have shed light on the pathways that result in tissue-specific eosinophil phenotypes. In this review, we discuss the process of tissue adaptation covering the local environmental cues that trigger adaptation, the transcriptional reprograming that occurs in response, and the phenotypic, metabolic, and functional adaptation that leads to varied eosinophil populations across the body. We further examine the relative impact of trained immunity and systemic factors versus local signals on eosinophil plasticity in the context of homeostasis and inflammation.
Fields of Study & Subjects
Immune responses and vaccinations
Immunodeficiency and Autoimmune Disorders
IL-33
ST2
and ILC Pathways
Publication details
- Journal / source
- Journal of Leukocyte Biology
- Publisher
- Oxford University Press (OUP)
- Volume
- 118
- Issue
- 6
- Publication date
- 16 May 2026
- Language
- EN