Salvage of locoregionally recurrent head and neck cancer: an NRG oncology working group review

JNCI Journal of the National Cancer Institute 2026 Open access

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Authors: Matthew C. Ward, Jung Julie Kang, Nabil F. Saba, Shauna R. Campbell, Neal S. Akhave, Steven S. Chang, Sharon A. Spencer, Anna Spreafico, Glenn J Hanna, Sue S Yom, Dwight Earl Heron
DOI: 10.1093/jnci/djag025
Cited by: 1
References: 59

Abstract

Despite decades of progress in the treatment of head and neck cancer, recurrence and second primary cancers continue to occur. The management of nonmetastatic, locoregionally recurrent or second primary cancers is a complex multidisciplinary challenge that often occurs without guidance from robust clinical trials. In 2023, the NRG Oncology cooperative group created the Recurrent and Metastatic Working Group with the express directive to investigate how resources could optimally address the key questions for the recurrent and metastatic populations. Here, we present our view of the state of the science and present considerations for future investigations.

Fields of Study & Subjects

Head and Neck Cancer Studies Oral Health Pathology and Treatment Cancer Diagnosis and Treatment

Publication details

Journal / source
JNCI Journal of the National Cancer Institute
Publisher
Oxford University Press (OUP)
Volume
118
Issue
7
Pages
1174–1182
Publication date
29 January 2026
Language
EN