Premenopausal and postmenopausal obesity and endometrial cancer risk: circulating biomarkers of inflammation, insulin resistance, and sex hormones as mediators

JNCI Journal of the National Cancer Institute 2026

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Authors: Sabrina E. Wang, Vivian Viallon, Carine Biessy, Tracy O'Mara, Maria Kyrgiou, Laura Burney Ellis, Emma J. Davidson, Holly Baker‐Rand, James Yarmolinsky, Pekka Keski‐Rahkonen, Mattias Johansson, Agnès Fournier
+19 more Marianne Canonico, Sabine Naudin, Renée T. Fortner, Charlotte Le Cornet, Matthias Schulze, Marta Crous‐Bou, Maria-Jose Sánchez, Amaia Aizpurua, Natalia Cabrera Castro, Marcela Guevara, Giovanna Masala, Rosario Tumino, Marı́a Teresa Giraudo, Camilla Panico, Ruth C. Travis, Marc J Gunter, Sabina Rinaldi, S Ghazaleh Dashti, Laure Dossus
DOI: 10.1093/jnci/djag119
Cited by: 1
References: 32

Abstract

BACKGROUND: Obesity may increase endometrial cancer risk through pathways involving chronic inflammation, insulin resistance, and altered sex hormone levels. METHODS: Within the European Prospective Investigation into Cancer and Nutrition cohort, we investigated these mediating pathways using prediagnostic circulating biomarkers measured in 337 matched case-control pairs with postmenopausal measurements and 196 pairs with premenopausal measurements. We estimated the natural indirect effect (NIE) of obesity (body mass index ≥30 kg/m2 vs

Fields of Study & Subjects

Endometrial and Cervical Cancer Treatments Adipokines Inflammation and Metabolic Diseases Menopause: Health Impacts and Treatments

Publication details

Journal / source
JNCI Journal of the National Cancer Institute
Publisher
Oxford University Press (OUP)
Volume
118
Issue
9
Pages
1682–1691
Publication date
17 April 2026
Language
EN