RNA-directed DNA methylation: epigenome-guided herbicide-tolerant crop management

Journal of Experimental Botany 2026

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Authors: Madhab Kumar Sen, Amit Roy, Sunil Kanti Mondal, Kateřina Hamouzová, Mukesh Jain
DOI: 10.1093/jxb/erag094
Cited by: 0
References: 43

Abstract

RdDM offers a programmable epigenetic route to herbicide tolerance without altering DNA sequences. This review highlights RdDM control of detoxification, transport, and stress networks, and outlines tools to map and engineer adaptive epialleles. We further discuss the stability, reversibility, and transgenerational inheritance of RdDM-mediated changes, emphasizing their potential for sustainable crop improvement. By integrating epigenome editing, small RNA biology, and stress physiology, we propose strategic frameworks to harness RdDM for precision breeding and climate-resilient agriculture.

Fields of Study & Subjects

Epigenetics and DNA Methylation Genetically Modified Organisms Research CRISPR and Genetic Engineering

Publication details

Journal / source
Journal of Experimental Botany
Volume
77
Issue
12
Pages
3472–3480
Publication date
18 February 2026
Language
EN