Iterative design of a NAND hybrid riboswitch by deep batch Bayesian optimization

Nucleic Acids Research 2026 Open access

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Authors: Daniel Kelvin, Erik Kubaczka, Marianna Karava, Heinz Koeppl, Beatrix Suess
DOI: 10.1093/nar/gkag145
Cited by: 3
References: 73

Abstract

The design of large genetic circuits requires genetic regulatory devices capable of performing complex logic operations that place no excessive metabolic burden on the host cell. Hybrid riboswitches, synthetically enhanced compact RNA elements (

Fields of Study & Subjects

RNA and protein synthesis mechanisms Gene Regulatory Network Analysis RNA modifications and cancer

Publication details

Journal / source
Nucleic Acids Research
Publisher
Oxford University Press (OUP)
Volume
54
Issue
5
Publication date
9 February 2026
Language
EN