The deleterious effect of proteinuria in residual kidney function in hemodialysis patients

Nephrology Dialysis Transplantation 2026

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Authors: Beatriz Sánchez Álamo, Irene Mínguez Toral, Martha Elizabeth Díaz Domínguez, Nuria Rodríguez Mendiola, Milagros Fernández Lucas
DOI: 10.1093/ndt/gfag058
Cited by: 0
References: 30

Abstract

BACKGROUND: Residual kidney function (RKF) is a major prognostic determinant in hemodialysis (HD), strongly influencing morbidity, mortality and quality of life. Although proteinuria is a well-established marker of chronic kidney disease progression, its prognostic relevance at the initiation of HD remains uncertain. This study aimed to assess the association between baseline proteinuria and RKF decline during the first year of HD. METHODS: We performed a prospective study of incident online hemodiafiltration (online-HDF) patients with preserved RKF, defined as kidney urea clearance (KrU) ≥2.5 mL/min and urine output >500 mL/day. The primary endpoint was RKF loss at 1 year, defined as KrU

Fields of Study & Subjects

Dialysis and Renal Disease Management Chronic Kidney Disease and Diabetes Acute Kidney Injury Research

Publication details

Journal / source
Nephrology Dialysis Transplantation
Volume
41
Issue
10
Pages
1868–1877
Publication date
12 March 2026
Language
EN