Discovery of genetic susceptibility variants in pediatric and adult ependymoma

Neuro-Oncology Advances 2026 Open access

Read full text
Authors: J Strauss, Priya Bhatia Shetty, Spiridon Tsavachidis, Jinyoung Byun, Stephen C. Mack, Xiao Xiangjun, Terri S. Armstrong, Mark R Gilbert, (on behalf of NCI-CONNECT), Lisa J. Mirabello, Smita Bhatia, Wendy M. Leisenring
+13 more Lindsay McOmber Morton, Gregory T. Armstrong, Jon Foss-Skiftesvik, Christian M. Hagen, Jonas Bybjerg‐Grauholm, Manel Ghozal, Audrey Bonaventure, Jacqueline Clavel, Melissa L. Bondy, (on behalf of GICC), Christopher Ian Amos, Thanh T. Hoang, Michael E. Scheurer
DOI: 10.1093/noajnl/vdag004
Cited by: 0
References: 43

Abstract

Abstract Background Ependymoma is a malignancy of the neuroepithelium-derived ependyma that lines the spinal cord and ventricles of the brain, occurring most frequently in young children and older adults. Genetic susceptibility to ependymoma has proven difficult to assess due to disease rarity. Methods We performed genome-wide association studies (GWAS) of 478 ependymoma patients and 4,841 disease-free controls of European ancestry. Ependymoma patients consisted of 117 children (

Fields of Study & Subjects

Glioma Diagnosis and Treatment Genetic Associations and Epidemiology Cancer Genomics and Diagnostics

Publication details

Journal / source
Neuro-Oncology Advances
Volume
8
Issue
1
Pages
vdag004–vdag004
Publication date
1 January 2026
Language
EN