Prognostic impact of circulating vitamin D and genetic variants in the vitamin D pathway in glioblastoma

Neuro-Oncology Advances 2026 Open access

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Authors: Mariangela Morelli, Francesca Di Lorenzo, Francesca Marchetto, Michele Menicagli, Sara Franceschi, Manuel Giacomarra, Carlo Gambacciani, Francesco Pieri, Francesco Pasqualetti, Paolo Aretini, Colin Gerard Egan, Silvia Trasciatti
+7 more Santina Battaglia, Linda Solfanelli, Fabrizio Nannipieri, Orazio Santo Santonocito, Anna Luisa Di Stefano, Francesca Lessi, Chiara Maria Mazzanti
DOI: 10.1093/noajnl/vdag158
Cited by: 1
References: 54

Abstract

Abstract Background Vitamin D (VitD) signaling is implicated in cancer and immune regulation, but its role in glioblastoma (GBM) remains unclear. We investigated the prognostic impact of VitD levels, VDR expression, and polymorphisms in VitD-related genes in GBM. Methods Ninety GBM tumors (62 primary, 28 recurrent) were analyzed. Circulating 25-hydroxyvitamin D (25(OH)D) was measured in 54 cases; tumor VDR mRNA/protein, calcitriol, and CYP24A1/CYP27B1/CYP27A1 proteins were assessed. Whole-exome sequencing identified SNPs in the VitD-pathway genes. Associations with overall (OS) and progression-free survival (PFS) were evaluated by Kaplan-Meier and Cox models. Transcriptomic profiles were explored by GSEA. Results Severe 25(OH)D deficiency (

Fields of Study & Subjects

Vitamin D Research Studies Cancer Hypoxia and Metabolism Neuroblastoma Research and Treatments

Publication details

Journal / source
Neuro-Oncology Advances
Publisher
Oxford University Press (OUP)
Volume
8
Issue
1
Pages
vdag158–vdag158
Publication date
1 January 2026
Language
EN