P-1279. Five-year trend analysis of carbapenem-resistant Enterobacterales, including isolates carrying metallo-β-lactamase genes in United States, Europe and adjacent regions during 2020–2024

Open Forum Infectious Diseases 2026 Open access

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Authors: Mariana Castanheira, John H. Kimbrough, Zachary Kockler, Rodrigo Elisandro Mendes
DOI: 10.1093/ofid/ofaf695.1469
Cited by: 0

Abstract

Abstract Background Carbapenem-resistant Enterobacterales (CRE) isolates are an urgent human health treat. Different from serine-carbapenemase-producing isolates for which active antimicrobial agents are clinically available, metallo-β-lactamase (MBL)-producing organisms are still an unmet need with limited therapeutic choices in clinical use in most countries. We evaluated the prevalence of CREs and MBL-carrying isolates in a 5-year surveillance study in European (includes Israel and Turkey) and US hospitals.Percentage of CRE and MBL-producing isolates by year*Statistically significant trend (p

Fields of Study & Subjects

Antibiotic Resistance in Bacteria Antibiotic Use and Resistance Enterobacteriaceae and Cronobacter Research

Publication details

Journal / source
Open Forum Infectious Diseases
Volume
13
Issue
Supplement_1
Publication date
1 January 2026
Language
EN