P-1556. IFITM3 Genetic Variant rs34481144 and Increased Risk of Hypoxemia in Children infected with Influenza

Abstract Background Influenza remains a major cause of pediatric morbidity and mortality worldwide. Several factors can increase the risk of severe disease. IFITM3 protein is a critical antiviral factor restricting influenza virus infection. The single nucleotide polymorphism (SNP) rs34481144 (C/T) in IFITM3 has been associated with impaired immune responses, including reduced airway CD8⁺ T cells. We aimed to determine whether the rs34481144 variant is associated with influenza infection severity in children. *Mild = not requiring supplemental oxygen therapy; Severe = requiring of supplemental oxygen therapy.**Immunization status, including Influenza vaccination (mandatory and free of charge for all patients