P-317. Efficacy of CCR5 Gene Editing via CRISPR-Cas9 in HIV/AIDS Prevention: A Meta-Analysis

Abstract Background HIV-1 remains a major global health challenge. The CCR5 receptor on CD4+ T cells is key for viral entry. Individuals homozygous for the CCR5Δ32 mutation show natural resistance to HIV, suggesting that gene inactivation may offer protection. CRISPR-Cas9 editing has emerged as a strategy to mimic this effect. This meta-analysis evaluates the efficacy and safety of CCR5 editing via CRISPR-Cas9 in HIV-1 prevention.Summary of Meta-Analysis ResultsBar graph showing key findings from the meta-analysis: 74.5% reduction in HIV-1 susceptibility after CCR5 editing, 86% higher protection in biallelic versus monoallelic editing, and 78% viral load decrease following SHIV challenge.Forest Plot of CCR5 Gene Editing Effectiveness Forest plot illustrating the pooled odds ratio (OR=0.22; 95% CI: 0.14–0.33; p