P-511. Preliminary results of clinical signs and brain imaging findings among neonates with Congenital Cytomegalovirus identified through the U.S. Surveillance for Emerging Threats to Mothers and Babies Network (SET-NET), 2014-2023

Abstract Background Congenital cytomegalovirus (cCMV) is the most common infectious cause of birth defects and non-genetic hearing loss in U.S. children. Variations in cCMV screening practices and the absence of national cCMV surveillance in the U.S. hinders assessment of disparities in disease burden, clinical care, and intervention. We describe clinical characteristics of neonates with cCMV identified through a novel surveillance program.Table 1.Clinical signs, neuroimaging, and treatment among neonates with congenital cytomegalovirus disease or confirmed infection status — Surveillance for Emerging Threats to Pregnant People and Infants Network 2014–2023 (N=387 neonates)1 Some neonates classified as having cCMV infection at birth may go on to develop signs and symptoms later (e.g., sensorineural hearing loss, cerebral palsy) which would move them to a cCMV disease classification. Follow up is ongoing, and these results are preliminary. Additionally, 60% of infection cases came from Minnesota where a universal screening program is in place.2Reported in the medical record or a reported head circumference