Prevalence of CSF HIV VIRAL Escape and Associations With Neurocognitive Outcomes Among HIV-Associated Meningitis Survivors: A Cohort Study

Open Forum Infectious Diseases 2026 Open access

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Authors: Laura Nsangi, Gila Hale, Biyue Dai, Kathy Huppler Hullsiek, Asmus Tukundane, Alice Namudde, Grace Menya, Peruth Ayebare, Lydia Nankungu, Olivie Carolyne Namuju, Susan Mulwana, Mable Kabahubya
+6 more David B. Meya, David R. Boulware, Fiona V Cresswell, Nathan C. Bahr, Mahsa Abassi, Jayne P. Ellis
DOI: 10.1093/ofid/ofag016
Cited by: 0
References: 19

Abstract

Among this prospective cohort of 93 Ugandan adults who survived HIV-associated cryptococcal or tuberculous meningitis, baseline secondary cerebrospinal fluid (CSF) HIV viral escape was highly prevalent and was associated with better neurocognitive outcomes at 3 months. Individuals with secondary CSF HIV viral escape were more likely to be antiretroviral therapy-naïve and to exhibit CSF pleocytosis.

Fields of Study & Subjects

HIV Research and Treatment Infectious Diseases and Tuberculosis HIV/AIDS Research and Interventions

Publication details

Journal / source
Open Forum Infectious Diseases
Volume
13
Issue
2
Pages
ofag016–ofag016
Publication date
9 January 2026
Language
EN