Pretransplant CMV-IgG Titers and DNAemia Are Associated With CMV Infections Post Allogeneic Hematopoietic Cell Transplant With or Without Letermovir

Open Forum Infectious Diseases 2026 Open access

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Authors: Léna Royston, Ming Zou, Federico Simonetta, Manuel Schibler, Sabine Yerly, Amandine Pradier, Federica Giannotti, Anne‐Claire Mamez, Sarah Morin, Christian van Delden, Laurent Kaiser, Yves Chalandon
+2 more Stavroula Masouridi‐Levrat, Dionysios Neofytos
DOI: 10.1093/ofid/ofag068
Cited by: 0
References: 16

Abstract

Abstract Background The impact of pretransplant cytomegalovirus (CMV) serology and DNAemia on posttransplant clinically significant CMV infections (csCMVi) in allogeneic hematopoietic cell transplant recipients (allo-HCTR) is poorly described. Methods We performed a single-center cohort study of adult allo-HCTR (16 November 2015–31 December 2023). Letermovir prophylaxis was administered after 01 May 2019 during 100 days (d) posttransplant in CMV-seropositive patients (R+). We investigated associations of pretransplant CMV-IgG-titers and CMV-DNAemia with posttransplant csCMVi and CMV-DNAemia during 6 months posttransplant. In CMVR+, CMV-IgG-titers were classified as “low” (

Fields of Study & Subjects

Cytomegalovirus and herpesvirus research Viral-associated cancers and disorders Hematopoietic Stem Cell Transplantation

Publication details

Journal / source
Open Forum Infectious Diseases
Volume
13
Issue
2
Pages
ofag068–ofag068
Publication date
1 February 2026
Language
EN