Use of DOOR and Win-Ratio Analysis in a Secondary Evaluation of a Histoplasmosis Clinical Trial

Open Forum Infectious Diseases 2026 Open access

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Authors: Tarsila Vieceli, Biyue Dai, Diego R. Falci, Daiane Flores Dalla Lana, Cassia S M Godoy, Renata B A Soares, Mônica Baumgardt Bay, Hareton Teixeira Vechi, Terezinha do Menino Jesus Silva Leitão, Lisandra Serra Damasceno, Marineide Gonçalves de Melo, Nathan C. Bahr
+2 more David R. Boulware, Alessandro Comarú Pasqualotto
DOI: 10.1093/ofid/ofag089
Cited by: 0
References: 13

Abstract

Hierarchical composite end points may better reflect patient outcomes, rather than mortality alone. We applied DOOR and Win-Ratio analyses to a phase II trial comparing single high-dose vs standard liposomal amphotericin B for HIV-associated histoplasmosis. No clear differences were observed, supporting feasibility and informing design of future phase III trials.

Fields of Study & Subjects

Statistical Methods in Clinical Trials Fungal Infections and Studies Antifungal resistance and susceptibility

Publication details

Journal / source
Open Forum Infectious Diseases
Volume
13
Issue
3
Pages
ofag089–ofag089
Publication date
23 February 2026
Language
EN