Evaluation of the MEFIER Score in Identifying Patients at High Risk of Endocarditis in Enterococcus faecalis Bacteremia

Open Forum Infectious Diseases 2026 Open access

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Authors: Virgile Zimmermann, Nicolas Fourré, Pierre Monney, Georgios Tzimas, L Senn, Lars Niclauss, Matthias Kirsch, Benoit P. Guery, Matthaios Papadimitriou-Olivgeris
DOI: 10.1093/ofid/ofag184
Cited by: 1
References: 19

Abstract

Abstract In a retrospective cohort of 549 Enterococcus faecalis bacteremia episodes, the MEFIER score showed poor rule-out performance (negative likelihood ratio of 0.69), misclassifying 60% of IE episodes as low-risk. In contrast, DENOVi score achieved a low negative likelihood ratio (0.07), misclassifying only 5% while limiting unnecessary echocardiography.

Fields of Study & Subjects

Infective Endocarditis Diagnosis and Management Streptococcal Infections and Treatments Antimicrobial Resistance in Staphylococcus

Publication details

Journal / source
Open Forum Infectious Diseases
Publisher
Oxford University Press (OUP)
Volume
13
Issue
4
Pages
ofag184–ofag184
Publication date
26 March 2026
Language
EN