Kaposi Sarcoma-Associated Immune Reconstitution Inflammatory Syndrome (KS-IRIS) in Advanced HIV: Challenges in Managing Visceral Disease With Pericardial Involvement
Abstract
Immune reconstitution inflammatory syndrome (IRIS) is a well-described complication following initiation of antiretroviral therapy (ART) in people with HIV. In this case report, we describe the complex clinical presentation of a 27-year-old ART-naïve male with advanced HIV who developed Kaposi sarcoma-associated IRIS (KS-IRIS) with visceral involvement and pericardial effusion shortly after starting ART. We review known risk factors for KS-IRIS, its clinical manifestations including rare cardiac involvement and paradoxical worsening with steroid use, as well as current evidence for chemotherapeutic and antiviral treatment strategies.
Fields of Study & Subjects
Viral-associated cancers and disorders
HIV-related health complications and treatments
Pericarditis and Cardiac Tamponade
Publication details
- Journal / source
- Open Forum Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Volume
- 13
- Issue
- 6
- Pages
- ofag363–ofag363
- Publication date
- 1 June 2026
- Language
- EN