Tenofovir-induced Fanconi syndrome: a case report and literature review

Abstract Tenofovir disoproxil fumarate (TDF) is an antiviral medication with potential nephrotoxicity side effects. In this case report, a patient who had been taking TDF for five years was referred to nephrology clinic for hypophosphatemia. Additional labs demonstrated urinary phosphate wasting, glucosuria, hypokalemia, and hyperchloremic metabolic acidosis. Imaging revealed occult fractures. She was diagnosed with tenofovir-induced Fanconi syndrome with hypophosphatemic osteomalacia. TDF was switched to tenofovir alafenamide (TAF) and electrolyte deficiencies were treated with supplementation. However, phosphaturia and glucosuria persisted, prompting TAF switch to entecavir, which improved serum electrolytes and quality of life. Mild Fanconi syndrome was present at 6 months after TAF discontinuation, which highlights that tenofovir can have prolonged effects on proximal tubule dysfunction. Delays in the diagnosis of tenofovirinduced tubular toxicity can be avoided through surveillance labs every six months that include basic blood electrolytes and phosphorus, and urinalysis to screen for glucosuria.