Spatial genomics and brain spatial transcriptomic atlas for precision medicine

The emergence of spatial genomics has introduced new possibilities to studying structure-function relationships in neuropsychiatric disorders. Spatial transcriptomics (ST) allows the detection of thousands of genes simultaneously up to single-cell resolution which holds spatial location of gene transcriptional activity within a tissue sample. Spatial genomics technologies are developed rapidly, and many of them were used for constructing brain spatial genomics atlases. A brain spatial transcriptomic atlas is a map of the gene expression across brain regions in situ—that is, within their anatomical context—often at single-cell or near-single-cell resolution. The brain spatial genomics atlas has been constructed for a few species including mice and humans. These brain atlases can be used to further investigate specific genes or pathways that are dysregulated in disease, advancing therapeutic development as a result. The spatial genomics and brain ST atlas are vital for driving precision medicine efforts for neurological disorders.