Physical decellularization of fish skin utilizing electrical fields

Regenerative Biomaterials 2026 Open access

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Authors: Mengshi Chen, Siyi Chen, Yapei Song, Siran Wang, Zheng Qiaoyin, You Zhifeng, Weijie Peng, Huaqiong Li, Feng Wen
DOI: 10.1093/rb/rbag005
Cited by: 1
References: 45

Abstract

Decellularized tissues have attracted considerable attention in tissue engineering and regenerative medicine due to their diverse sources and excellent biocompatibility. However, current decellularization techniques often compromise the integrity of the extracellular matrix, leaving harmful chemical residues or inadequately removing immunogenic cellular components. Consequently, the biocompatibility and clinical efficacy of decellularized tissues are undermined. To address these issues, a novel decellularization technique employing an electrical field has been proposed. In the resulting decellularized tissue, the residual DNA concentration was measured at 27.44 ± 7.27 ng/mg, satisfying the evaluation criteria (

Fields of Study & Subjects

Tissue Engineering and Regenerative Medicine Wound Healing and Treatments Electrospun Nanofibers in Biomedical Applications

Publication details

Journal / source
Regenerative Biomaterials
Publisher
Oxford University Press (OUP)
Volume
13
Pages
rbag005–rbag005
Publication date
1 January 2026
Language
EN