107. Intervention study of traditional chinese medicine on patients with mild to moderate Alzheimer’s disease

Abstract Background Alzheimer’s Disease (AD) is a neurodegenerative disease characterized by the gradual weakening of cognitive function. Patients with mild to moderate AD often present with impaired attention allocation and executive function, significantly affecting daily life. Current pharmacological treatments, mainly cholinesterase inhibitors, provide limited benefits and may cause gastrointestinal side effects. Currently, traditional Chinese medicine (TCM) interventions based on neuroprotection and anti-inflammatory mechanisms have gained attention. Evidence suggests that early intervention before clinical symptom manifestation can delay disease progression, similar to the predictive role of early neurophysiological abnormalities in psychotic risk syndromes such as P300 amplitude reduction. Therefore, this study conducted experimental verification to investigate the cognitive improvement and potential disease-delaying effects of TCM intervention in cases with mild to moderate AD. Methods The 180 patients who met the diagnostic criteria for mild to moderate AD were included and then randomly separated into an experimental group (EG, n = 90) and a control group (CG). The EG received a compound TCM preparation containing Gastrodia elata, Salvia miltiorrhiza, Polygala tenuifolia, and Acorus tatarinowii, administered twice daily for 24 consecutive weeks; the CG received standard Western pharmacotherapy. Both groups were provided with health education and routine rehabilitation training. The Mini-Mental State Examination (MMSE) and the Montreal Cognitive Assessment (MoCA) were used to assess cognitive function before and after the intervention, and record behavioral abnormalities and changes in living abilities. Repeated measures ANOVA was taken for statistical comparison (p