Sleep duration associations with CSF-tissue coupling flexibility and circadian synchronization: an observational study of glymphatic-related dynamics

SLEEP 2026

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Authors: Min Jeong Kwon, Jae‐Joong Kim, Jae‐Joong Kim, Sungman Jo, Youjung Choi, Jae‐Joong Kim, Dong-Hyun Kim, Ji Won Han, Ki Woong Kim
DOI: 10.1093/sleep/zsag159
Cited by: 1
References: 48

Abstract

STUDY OBJECTIVES: The glymphatic system clears brain waste and is most active during sleep. How habitual sleep duration influences its diurnal function in humans remains unclear. We examined whether individuals with longer habitual sleep duration exhibit enhanced diurnal glymphatic fluctuations characterized by flexible cerebrospinal fluid (CSF)-tissue coupling and synchronized temporal dynamics compared with those with shorter sleep duration. MATERIALS AND METHODS: In this cross-sectional study, 25 healthy adults (mean age 26.5 years; 52% women) underwent multimodal MRI at 8 a.m., 2 p.m., and 8 p.m. on a single day. Participants were stratified into long (≥404 minutes, n = 14) and short (

Fields of Study & Subjects

Cerebrospinal fluid and hydrocephalus Neurological disorders and treatments Spinal Dysraphism and Malformations

Publication details

Journal / source
SLEEP
Publisher
Oxford University Press (OUP)
Volume
49
Issue
9
Publication date
10 June 2026
Language
EN