A biophysical basis for the diffusion-restricted behavior of Xist RNA

2026 Dataset

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DOI: 10.1096/phase2026.s05.p01
Cited by: 0

Abstract

Xist RNA initiates X inactivation as it spreads in cis across the chromosome. Here, we reveal a biophysical basis for its cis-limited diffusion. Xist RNA and HNRNPK together drive a liquid-liquid phase separation (LLPS) that encapsulates the chromosome.

Fields of Study & Subjects

RNA Research and Splicing Genomics and Chromatin Dynamics Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities

Publication details

Publication date
24 February 2026
Language
EN
Document type
Dataset