Pregnancy Outcomes in Women With Liver Cirrhosis: A National Prospective Cohort Study Using the UK Obstetric Surveillance System

Obstetric Anesthesia Digest 2026

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Authors: Melanie Nana, Agata Majewska, Mussarat Nazia Rahim, Geenes, Caroline Ovadia, M Knight, Michael Heneghan, Catherine Williamson
DOI: 10.1097/01.aoa.0001178592.95770.de
Cited by: 0

Abstract

( BJOG . 2025; 132:935–943. doi: 10.1111/1471-0528.18107) Cirrhosis is estimated to affect 45 per 100,000 women of childbearing potential with varying etiologies observed globally including viral hepatitis, nonalcoholic steatohepatitis, alcohol-associated liver disease, autoimmune hepatitis, and genetic disorders. Due to low fertility rates, pregnancy was historically uncommon leading to a lack of available evidence. The available evidence described a higher risk of maternal and neonatal mortality, especially for patients with esophageal varices and portal hypertension—although contemporary reports are more reassuring. This study aimed to describe the incidence of cirrhosis in pregnancy and detail maternal and neonatal outcomes.

Fields of Study & Subjects

Liver Disease and Transplantation Cardiovascular Issues in Pregnancy Liver Diseases and Immunity

Publication details

Journal / source
Obstetric Anesthesia Digest
Volume
46
Issue
1
Pages
8–9
Publication date
1 March 2026
Language
EN