No Effect of Tetracosactide for Treatment of Postdural Puncture Headaches in Parturient Women: A Double-blind Randomized Controlled Clinical Trial

Obstetric Anesthesia Digest 2026

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Authors: Mikhail A. Dziadzko, Lionel Bouvet, Nadia Steer, Célia Depaulis, Pierre Pradat, F Joubert, Laure Lalande, D Chassard, Frédéric Aubrun
DOI: 10.1097/01.aoa.0001178632.33538.e3
Cited by: 0

Abstract

( Br J Anaesth . 2025;135:148-154 doi: 10.1016/j.bja.2025.04.012) This randomized, double-blind, placebo-controlled clinical trial investigated whether tetracosactide, a synthetic analogue of adrenocorticotropic hormone (ACTH), could effectively treat postdural puncture headache (PDPH) in postpartum women who received neuraxial anesthesia. Conducted at 2 tertiary maternal hospitals in France, the study sought to evaluate if a single intravenous dose of tetracosactide could reduce the need for an epidural blood patch (EBP), the current gold-standard invasive treatment for PDPH.

Fields of Study & Subjects

Neurosurgical Procedures and Complications Anesthesia and Pain Management Migraine and Headache Studies

Publication details

Journal / source
Obstetric Anesthesia Digest
Volume
46
Issue
1
Pages
17–18
Publication date
1 March 2026
Language
EN