Acute coronary syndrome during active infusion of andexanet alfa
Abstract
ABSTRACT: Now withdrawn from the US market, andexanet alfa was initially approved by the FDA in 2018 to reverse life-threatening bleeds associated with factor Xa (FXa) inhibitors, specifically apixaban and rivaroxaban. Observed effects of andexanet alfa include a reduction in anti-FXa activity resulting in hemostatic efficacy. However, thrombotic events including myocardial infarction and deep venous thrombosis, typically occurring 6 to 30 days after infusion, have also been observed. This case presents the first known patient to develop an ST-segment elevation myocardial infarction while actively receiving infusion of andexanet alfa, which was an approved therapy at the time of the patient's treatment.
Fields of Study & Subjects
Atrial Fibrillation Management and Outcomes
Acute Myocardial Infarction Research
Heparin-Induced Thrombocytopenia and Thrombosis
Publication details
- Journal / source
- JAAPA
- Publisher
- Ovid Technologies (Wolters Kluwer Health)
- Volume
- 39
- Issue
- 7
- Pages
- e5–e8
- Publication date
- 23 June 2026
- Language
- EN