Predicting Nonresponse to Multicomponent Treatment in Fibromyalgia

Clinical Journal of Pain 2026

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Authors: Rodrigo López-García, Mayte Serrat, Juan P. Sanabria‐Mazo, Adrián Pérez-Aranda, Míriam Almirall, Jaime Delgadillo, Albert Espelt, Juan Vicente Luciano, Rubén Nieto, Albert Feliu-Soler
DOI: 10.1097/ajp.0000000000001367
Cited by: 1
References: 70

Abstract

BACKGROUND: Multicomponent programs combining therapeutic exercise, cognitive-behavioral therapy, and pain neuroscience education demonstrate overall efficacy for fibromyalgia (FM). However, a substantial proportion of patients do not achieve clinically meaningful improvement. This study aimed to identify predictors of nonresponse and to develop a prognostic classifier model. METHODS: Participants (n=788) from multiple randomized controlled trials received a standardized 12-week multicomponent intervention. This secondary analysis defined nonresponse as a

Fields of Study & Subjects

Fibromyalgia and Chronic Fatigue Syndrome Research Psychosomatic Disorders and Their Treatments Musculoskeletal pain and rehabilitation

Publication details

Journal / source
Clinical Journal of Pain
Publisher
Ovid Technologies (Wolters Kluwer Health)
Volume
42
Issue
5
Publication date
2 March 2026
Language
EN