U.S. Racial and Ethnic Disparities in Outcomes Using Preimplantation Genetic Testing for Aneuploidies

OBJECTIVE: To determine live birth, intrauterine pregnancy, and miscarriage rates in cycles using preimplantation genetic testing for aneuploidy (PGT-A) as a function of race and ethnicity. METHODS: This retrospective cohort analysis used data collected from the Society of Assisted Reproductive Technology Clinical Outcomes Reporting System (SART CORS). Women who underwent their first autologous cycle that resulted in a primary transfer from 2014 to 2020 with the intent of assisted reproductive technology (ART) with and without PGT-A were included in this study. We compared live birth, intrauterine pregnancy, and miscarriage rates by race and ethnicity (American Indian/Alaska Native, Asian, Black, Hispanic, Native Hawaiian/Other Pacific Islander, and White). Statistical analyses of live birth, intrauterine pregnancy, and miscarriage rates with t tests and multiple logistic regression were used to determine adjusted odds ratios (aORs). RESULTS: A total of 438,583 ART cycles were included with 150,604 PGT-A and 287,979 non-PGT-A primary autologous cycles with a single blastocyst transfer. There was a decrease in live-birth rate in White women using PGT-A (37.4% vs 39.7%, P .05). Live-birth rates were similar in PGT-A cycles of Black and Hispanic women compared with non-PGT-A cycles. Asian women who used PGT-A had higher intrauterine pregnancy rate (34.7% vs 30.4%, P