Severe Necrotizing Locally Advanced Basal Cell Carcinoma With Osteomyelitis
Abstract
Locally advanced basal cell carcinoma (BCC) is an uncommon and complex presentation of BCC. These tumors can present as extensive nonhealing ulcers and require skin biopsy to rule out other causes, including malignant, infectious, and inflammatory etiologies. In this case report, a 57-year-old female without significant past medical history presented with a 5-year history of a chronic progressive ulcer involving the neck and back. Histopathological study of the tissue identified nodular and infiltrative BCC, prompting further multidisciplinary treatment and management with vismodegib, radiation, and surgery.
Fields of Study & Subjects
Nonmelanoma Skin Cancer Studies
Hedgehog Signaling Pathway Studies
Cancer and Skin Lesions
Publication details
- Journal / source
- Advances in Skin & Wound Care
- Volume
- 39
- Issue
- 3
- Pages
- E163–E165
- Publication date
- 26 February 2026
- Language
- EN