Microbiota in pancreatic ductal adenocarcinoma progression and therapy: The hidden players
Abstract
ABSTRACT: Pancreatic ductal adenocarcinoma (PDAC), the deadliest epithelial malignancy, is increasingly prevalent and contributes significantly to cancer-related mortality. Research over the past decade has demonstrated that microbiota may play a pivotal role in both PDAC oncogenesis and its resistance to chemotherapy. Emerging preclinical and clinical data highlight the impact of microbiota on therapeutic outcomes in PDAC patients. This review systematically explores the role and underlying mechanisms of microbiota in PDAC, with a particular focus on their clinical implications and translational potential in disease progression and therapeutic responses. Finally, this review addresses the potential of microbiome-based therapies to enhance the efficacy of PDAC treatments.
Fields of Study & Subjects
Pancreatic and Hepatic Oncology Research
Gut microbiota and health
Cancer Research and Treatments
Publication details
- Journal / source
- Chinese Medical Journal
- Publisher
- Ovid Technologies (Wolters Kluwer Health)
- Volume
- 139
- Issue
- 6
- Pages
- 843–854
- Publication date
- 3 February 2026
- Language
- EN